Creatine beta-hydroxybutyrate (Creatine BHB) is a relatively new compound in the realm of sports nutrition, combining creatine—a well-established ergogenic aid—with beta-hydroxybutyrate (BHB), a ketone body. The rationale for its use as an athletic and exercise aid stems from the substantial body of research supporting creatine monohydrate for increased power output, endurance, and recovery. Creatine supplementation is scientifically validated for enhancing high-intensity exercise performance, increasing muscle mass, and improving recovery, with hundreds of studies supporting these effects.

Beta-hydroxybutyrate, on the other hand, is used to elevate blood ketone levels and provide an alternative energy source during periods of low carbohydrate availability, such as ketogenic diets. Some preliminary studies suggest that exogenous ketone supplementation may reduce perceived exertion and muscle breakdown, and potentially enhance endurance, but robust evidence is lacking.

For the specific combination of creatine with BHB, direct scientific data is sparse. The theoretical benefit is the simultaneous delivery of creatine (for ATP regeneration) and BHB (as an alternative energy substrate), which might support performance during both anaerobic and aerobic exercise. However, as of mid-2024, there are very few, if any, peer-reviewed studies directly investigating the efficacy of creatine BHB for athletic performance in humans. The current use is therefore extrapolated from the individual benefits of creatine and BHB, not from direct evidence on their combination. Thus, the evidence rating is moderate at best.