Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Citrulline aspartate is used as an athletic and exercise aid primarily based on emerging scientific evidence. Citrulline, an amino acid, plays a key role in the urea cycle, helping to eliminate ammonia, a byproduct of intense exercise that can contribute to fatigue. Aspartate is also involved in energy production within the body. Several clinical studies have investigated the effects of citrulline aspartate supplementation on exercise performance and recovery. For example, some randomized controlled trials have shown that citrulline aspartate can reduce muscle fatigue and improve exercise performance, particularly in activities involving repeated bouts of high-intensity exercise or endurance. The proposed mechanisms include enhanced removal of ammonia, increased nitric oxide production leading to improved blood flow, and better aerobic energy production. A systematic review published in 2017 (Wax et al., Sports Medicine) indicated that citrulline supplementation may enhance exercise performance, though results are variable and more research is needed to standardize dosing and populations. Overall, the evidence is moderate (rated 3/5), with multiple small studies supporting its use, but lacking large-scale, long-term trials. It is not a traditional remedy, but rather a supplement with a basis in modern exercise physiology research. Further investigation is warranted to clarify optimal usage and confirm benefits in a wider range of athletes.

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