Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Citrulline alpha-ketoglutarate (CAKG) is a compound that combines L-citrulline, an amino acid, with alpha-ketoglutarate, an intermediate in the Krebs cycle. Its use as an athletic and exercise aid is primarily based on scientific rationale, though the direct evidence for this specific compound is limited and somewhat preliminary, warranting a modest evidence rating.

L-citrulline is known to increase plasma levels of arginine, which in turn can enhance nitric oxide (NO) production, theoretically improving blood flow, oxygen delivery, and nutrient transport to muscles during exercise. Some studies on L-citrulline (not specifically CAKG) have shown benefits such as reduced muscle soreness, improved exercise capacity, and enhanced strength performance, particularly in high-intensity or endurance exercise. Alpha-ketoglutarate, meanwhile, has been investigated for its potential to support energy metabolism and reduce muscle breakdown, though evidence in the context of exercise is sparse and less robust.

There is a lack of clinical trials specifically examining CAKG, as most research focuses on either L-citrulline or alpha-ketoglutarate separately. While the theoretical synergy is plausible, direct scientific validation for CAKG itself is limited. Therefore, while the use of citrulline-based supplements for athletic performance has some scientific basis, the evidence for the specific combination with alpha-ketoglutarate is not yet strong, and more research is needed to confirm its efficacy.

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