Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Arginine silicate inositol (ASI) is a dietary supplement often marketed as an athletic and exercise aid, primarily for its potential to enhance nitric oxide production and improve blood flow. Scientific evidence supporting its use is limited but growing. A few small, randomized controlled trials have suggested that ASI supplementation can increase plasma arginine levels and may enhance nitric oxide availability, leading to improved vasodilation. These effects theoretically support better oxygen and nutrient delivery to muscles during exercise, which could benefit performance and recovery.

In one published study, ASI supplementation in recreationally active men resulted in increased muscle pump (feeling of muscular fullness) and possibly improved exercise performance compared to placebo. Another trial noted improvements in markers of mental focus and perceived energy during exercise. However, these studies are generally limited by small sample sizes, short durations, and sometimes sponsorship from manufacturers.

Despite some promising findings, there is currently insufficient robust evidence to firmly conclude that ASI substantially enhances athletic performance or recovery. Most studies have not evaluated long-term safety or efficacy, and the magnitude of benefits observed is often modest. Therefore, while the scientific rationale is plausible and early results are positive, more high-quality, independent research is needed to substantiate the use of arginine silicate inositol as a significant athletic or exercise aid.

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