Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Arginine aspartate has been investigated as an ergogenic aid due to the individual roles of its components: arginine, an amino acid involved in nitric oxide (NO) production and vasodilation, and aspartate, which participates in the citric acid cycle and may reduce ammonia accumulation during intense exercise. Several early studies, mainly from the 1970s and 1980s, suggested that arginine aspartate supplementation might reduce fatigue and improve endurance during exercise, potentially by stimulating NO production (leading to increased blood flow) and by aiding in the removal of ammonia, a contributor to fatigue.

However, more recent and rigorous clinical trials have provided mixed or inconclusive results. Some research has failed to show a significant benefit of arginine aspartate over placebo in improving athletic performance, muscle strength, or recovery in healthy athletes. Systematic reviews and meta-analyses of amino acid supplementation generally indicate that arginine aspartate does not consistently yield measurable performance enhancement in trained individuals.

In summary, while there is a theoretical basis and some early (but not robust) scientific studies supporting the use of arginine aspartate as an exercise aid, the overall quality and consistency of evidence are limited. The use of arginine aspartate for athletic support has scientific origins, but its efficacy is not strongly validated by current research, resulting in a moderate evidence rating.

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