Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Alpha glyceryl, commonly referred to as alpha-glycerylphosphorylcholine (alpha-GPC), is used in some athletic and exercise aids due to its potential to enhance cognitive and physical performance. The primary scientific rationale for its use lies in its role as a choline source, which is a precursor for the neurotransmitter acetylcholine. Acetylcholine is involved in muscle contraction and cognitive functions. Several small-scale clinical studies have investigated alpha-GPC supplementation in athletes and physically active individuals. Some evidence suggests that alpha-GPC may increase growth hormone secretion and improve power output, particularly in resistance-trained individuals. For example, a double-blind, placebo-controlled study published in the "Journal of the International Society of Sports Nutrition" (2015) found that 600 mg of alpha-GPC taken 90 minutes before exercise significantly increased lower body force production compared to placebo.

However, the overall body of evidence is limited, with most studies involving small sample sizes and short durations. While results are promising, larger and more rigorous trials are necessary to confirm these benefits and to establish optimal dosing protocols. Currently, alpha-GPC is considered a “potentially beneficial” supplement for supporting acute exercise performance, primarily through its cognitive and neuromuscular effects, but the strength of evidence supporting its use as an athletic or exercise aid is moderate at best.

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