Evidence supporting the use of: Undecylenic acid
For the health condition: Athlete's Foot
Synopsis
Source of validity: Scientific
Rating (out of 5): 4
Undecylenic Acid for Athlete's Foot: Scientific Evidence
Undecylenic acid is a fatty acid derived from castor oil, and it has been widely used as a topical antifungal agent, especially in the treatment of Athlete's Foot (tinea pedis). There is a robust body of scientific evidence and regulatory approval supporting its efficacy. The United States Food and Drug Administration (FDA) has recognized undecylenic acid and its salts as safe and effective over-the-counter (OTC) treatments for superficial fungal infections, including Athlete's Foot. The mechanism of action involves disruption of fungal cell membranes, inhibiting the growth of dermatophytes such as Trichophyton species, which are the main causative agents of Athlete's Foot.
Numerous in vitro studies have demonstrated the antifungal activity of undecylenic acid against a range of pathogenic fungi. Clinical studies, though somewhat dated, report significant improvement in symptoms and reduction in fungal load when applied topically. For example, a 1950s study published in JAMA showed undecylenic acid preparations were as effective as other topical antifungals of the era. More recent reviews and laboratory studies confirm its continued efficacy and safety profile.
Given its FDA approval, long-standing clinical use, and demonstrated antifungal properties, the use of undecylenic acid for Athlete's Foot is primarily justified by scientific evidence. However, it is generally used for mild to moderate cases, and persistent or severe infections may require additional or systemic treatments.
Other ingredients used for Athlete's Foot
ajoenealoe vera
berberine
bisabolol
black walnut
garlic bulb
ginger
lauric acid
monolaurin
oregano
plantain
selenium
thyme
undecylenic acid
zinc
chickweed
shen-chu
neem tree
eucalyptus
camphor oil
menthol oil
herbal blend (proprietary)
melaleuca alternifolia
geranium
10-Undecenoic Acid
Apple Cider Vinegar
Alpha-terpineol
Allicin
Asteracea
allyl isothiocyanate
Babchi
Borate
Bee products
Coconut
Calendula
coconut oil
Carvacrol
Cajuput
Copaiba Oil
Essential Oil Blend
Glyceryl monolaurate
gamma-terpinene
Garlic