Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Glyceryl monolaurate (GML) is a naturally occurring monoglyceride that is recognized for its antimicrobial properties, including activity against bacteria, viruses, and some fungi. There is some scientific rationale for its use against tinea pedis (Athlete’s Foot), a condition caused by dermatophyte fungi such as Trichophyton species. Laboratory studies have demonstrated that GML can disrupt the membranes of certain fungi and inhibit their growth. For example, in vitro research has shown GML to be effective against Candida species and, to a lesser extent, some dermatophytes. However, the majority of these studies are preclinical (test tube or petri dish), and there is a lack of high-quality clinical trials evaluating the use of topical GML specifically for Athlete’s Foot in humans.

Despite its promising mechanism of action, the direct evidence for GML's efficacy in treating Athlete’s Foot is limited. There are no major clinical guidelines that recommend its use, and published human data are sparse. Its inclusion in some topical antifungal preparations is based on its broad antimicrobial profile and safety record, but this should be viewed as preliminary support rather than established therapy. Therefore, while there is a scientific basis for exploring GML as a treatment for Athlete’s Foot, the current level of evidence is modest, reflecting a need for robust clinical trials to confirm efficacy and safety in this context.

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