Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E has been investigated for its potential role in the prevention and treatment of arteriosclerosis (hardening and narrowing of the arteries) due to its antioxidant properties. The rationale behind its use is that oxidative stress contributes to the development of atherosclerotic plaques by oxidizing low-density lipoprotein (LDL) cholesterol, and antioxidants like vitamin E might inhibit this process. Historically, observational studies suggested that populations with higher dietary intake or blood levels of vitamin E had a lower risk of cardiovascular disease, including arteriosclerosis. This led to widespread interest and the initiation of large randomized controlled trials (RCTs) to test vitamin E supplementation directly.

However, results from major RCTs, such as the HOPE, GISSI-Prevenzione, and Women's Health Study, have consistently shown that vitamin E supplementation does not significantly reduce the risk of cardiovascular events or slow the progression of arteriosclerosis. Some studies have even raised concerns about potential harm at high doses. Systematic reviews and meta-analyses of these RCTs conclude that there is no clear benefit for vitamin E supplementation in the prevention or treatment of arteriosclerosis in the general population. As a result, while the use of vitamin E for arteriosclerosis is grounded in a scientific hypothesis and was widely promoted in the past, current evidence does not support its effectiveness for this condition.

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Other ingredients used for Arteriosclerosis

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