Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E (mixed tocopherols) has been investigated for its potential role in supporting or treating arteriosclerosis (also known as atherosclerosis), largely due to its antioxidant properties. The scientific rationale is that oxidative stress contributes to the oxidation of low-density lipoprotein (LDL) cholesterol, a key step in the development of arterial plaques. As a lipid-soluble antioxidant, Vitamin E could theoretically help prevent this process.

However, large randomized controlled trials and meta-analyses have not provided strong evidence for a beneficial effect of Vitamin E supplementation on the progression or prevention of arteriosclerosis or its clinical outcomes (such as heart attacks or strokes). For example, the Heart Outcomes Prevention Evaluation (HOPE) and the Physicians’ Health Study II found no significant reduction in cardiovascular events with Vitamin E supplementation. Some studies have even suggested potential risks with high-dose Vitamin E, including increased risk of hemorrhagic stroke.

Despite the biological plausibility and early observational studies suggesting benefit, the current scientific consensus does not support the routine use of Vitamin E supplements specifically for the treatment or prevention of arteriosclerosis. The evidence is rated as 2/5, reflecting limited and inconsistent support from clinical trials. Vitamin E remains important as part of a healthy diet, but supplementation for arteriosclerosis is not broadly recommended based on current evidence.

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