Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E (particularly alpha-tocopherol) has been investigated for its potential role in supporting or treating arteriosclerosis (hardening and narrowing of the arteries), mainly due to its antioxidant properties. The rationale is that oxidative modification of low-density lipoprotein (LDL) cholesterol in arterial walls contributes to atherosclerosis, and antioxidants like vitamin E might prevent or slow this process by neutralizing free radicals. Early epidemiological studies and some small clinical trials suggested a possible benefit of vitamin E supplementation in reducing cardiovascular events and slowing the progression of arteriosclerosis. However, larger and more recent randomized controlled trials (RCTs), such as the HOPE and GISSI-Prevenzione studies, have not found significant cardiovascular protection from vitamin E supplementation in the general population or in high-risk individuals. Meta-analyses have generally concluded that vitamin E does not reduce the risk of major cardiovascular events or slow the progression of arteriosclerosis, and high doses may even be associated with certain risks. Thus, while the use of vitamin E for arteriosclerosis is based on plausible scientific mechanisms and some early supportive evidence, the overall body of high-quality scientific data does not strongly support its routine use for this purpose.

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