Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E (mixed tocopherols) has been studied for its potential role in supporting cardiovascular health, including arteriosclerosis (hardening of the arteries). The interest in vitamin E stems from its antioxidant properties, as oxidative stress and lipid peroxidation are believed to contribute to the development of arteriosclerosis. Early epidemiological studies suggested an inverse relationship between vitamin E intake and cardiovascular disease risk. This led to several large randomized controlled trials (RCTs) investigating whether vitamin E supplementation could reduce the incidence or progression of arteriosclerosis and related cardiovascular events.

However, the results of these trials have largely been disappointing. Major studies such as the Heart Outcomes Prevention Evaluation (HOPE) and the Women's Health Study found that vitamin E supplementation did not significantly reduce the risk of major cardiovascular events or slow the progression of arteriosclerosis. Some studies even suggested potential harm at high doses. Meta-analyses of RCTs generally conclude that vitamin E supplementation offers little to no benefit in preventing or treating arteriosclerosis. Despite its biological plausibility and early promise, the body of scientific evidence does not strongly support the use of vitamin E for this purpose.

In summary, while the use of vitamin E for arteriosclerosis is scientifically motivated and has been investigated in clinical research, the overall strength of evidence supporting its efficacy is weak (rated 2/5).

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