Evidence supporting the use of: Rutin
For the health condition: Arteriosclerosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Rutin is a flavonoid commonly found in various fruits, vegetables, and plants such as buckwheat. Its use to support or treat arteriosclerosis (the thickening and hardening of arterial walls) is primarily justified by preclinical scientific evidence and some preliminary clinical studies, though robust human data are limited.

Laboratory and animal studies suggest that rutin exerts several potentially beneficial effects relevant to arteriosclerosis. These include antioxidant, anti-inflammatory, and vasoprotective activities. Rutin has been shown to reduce oxidative stress in blood vessels, inhibit low-density lipoprotein (LDL) oxidation (a key process in atherosclerotic plaque formation), and improve endothelial function. In animal models, rutin supplementation has resulted in reduced atherosclerotic plaque formation and improved vascular elasticity.

Human evidence is less consistent. Some small clinical studies have noted improvements in blood lipid profiles and markers of vascular health with rutin supplementation, but large, high-quality clinical trials specifically addressing arteriosclerosis are lacking. The mechanism is biologically plausible, but current evidence is not strong enough to recommend rutin as a stand-alone treatment for arteriosclerosis. Therefore, while scientific interest exists, the evidence base remains preliminary, justifying a score of 2 out of 5.

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