Evidence supporting the use of: Quercetin
For the health condition: Arteriosclerosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Quercetin, a flavonoid found in many fruits and vegetables, has been investigated for its potential role in supporting cardiovascular health, including conditions like arteriosclerosis. Scientific interest in quercetin stems from its antioxidant, anti-inflammatory, and vasodilatory properties. Preclinical studies in vitro and in animal models suggest that quercetin may inhibit the oxidation of low-density lipoprotein (LDL), reduce endothelial dysfunction, and decrease inflammatory markers involved in the progression of arteriosclerosis. Additionally, some research indicates that quercetin can suppress smooth muscle cell proliferation, a key step in the development of arterial plaque. However, human clinical trials remain limited and results are inconsistent. A few small randomized controlled trials have shown mild improvements in blood pressure and endothelial function with quercetin supplementation, but the evidence specifically for preventing or treating arteriosclerosis in humans is not robust. Most studies are short-term and do not directly measure changes in arterial plaque or clinical cardiovascular outcomes. Thus, while there is a scientific rationale for quercetin’s use based on laboratory and animal studies, solid clinical evidence is lacking. More large-scale, long-term human trials are needed to confirm any benefit for arteriosclerosis. Currently, the use of quercetin for arteriosclerosis is best described as an area of promising research rather than established therapy.

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