Evidence supporting the use of: Grape
For the health condition: Arteriosclerosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Grapes, particularly their skins and seeds, are rich in polyphenols such as resveratrol, flavonoids, and proanthocyanidins, which have been researched for their cardiovascular benefits, including potential roles in the prevention and management of arteriosclerosis (the thickening and hardening of arterial walls). Several clinical and epidemiological studies have demonstrated that regular consumption of grape products, especially red wine and grape seed extracts, is associated with improved endothelial function, reduced oxidative stress, and decreased inflammation—all factors implicated in arteriosclerosis development. For instance, resveratrol has been shown in laboratory and some human studies to inhibit LDL oxidation, suppress vascular smooth muscle cell proliferation, and reduce platelet aggregation, all of which contribute to atherogenesis.

However, while the mechanistic data and some small clinical trials are promising, large-scale, long-term randomized controlled trials specifically evaluating grape-derived products for the prevention or treatment of arteriosclerosis are lacking. Major health organizations recognize the cardiovascular benefits of diets rich in fruits (including grapes), but do not specifically recommend grape supplements for arteriosclerosis due to insufficient direct evidence. Thus, the use of grape is scientifically plausible and somewhat supported by preliminary evidence, but not yet established as a primary or stand-alone treatment. Its consumption as part of a balanced diet is currently the best-supported approach.

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