Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ginkgo biloba has been studied for its potential benefits in cardiovascular and cerebrovascular diseases, including arteriosclerosis (also known as atherosclerosis). The primary rationale for its use is its purported ability to enhance blood flow, reduce platelet aggregation, and provide antioxidant effects. Several laboratory and animal studies have shown that Ginkgo extracts may inhibit oxidative damage to blood vessels and reduce the progression of atherosclerotic plaque formation. Some human studies suggest that Ginkgo can improve markers of blood flow and endothelial function, which are relevant to arteriosclerosis.

However, clinical evidence in humans is limited and mixed. Most randomized controlled trials of Ginkgo focus on cognitive function or peripheral artery disease (e.g., intermittent claudication), rather than directly on arteriosclerosis itself. Meta-analyses indicate only modest benefit, if any, for these related vascular conditions. There is a lack of large, high-quality clinical trials demonstrating that Ginkgo biloba directly treats or reverses arteriosclerosis. As such, while there is a scientific rationale and some preliminary evidence, the overall quality and quantity of evidence supporting the use of Ginkgo for arteriosclerosis is low, and its use for this indication should be considered experimental.

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