Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavonols, a subclass of flavonoids commonly found in fruits, vegetables, tea, and wine, have been investigated for their potential cardiovascular benefits, including their role in the prevention and management of arteriosclerosis (the thickening and hardening of arterial walls). Scientific interest in flavonols stems from their antioxidant, anti-inflammatory, and endothelial-protective properties. Several epidemiological studies suggest that higher dietary intake of flavonol-rich foods is associated with reduced risk of cardiovascular diseases, including arteriosclerosis. Experimental and animal studies indicate that flavonols such as quercetin and kaempferol may inhibit LDL oxidation, decrease vascular inflammation, and improve endothelial function—processes implicated in the pathogenesis of arteriosclerosis.

However, direct clinical evidence supporting flavonol supplementation specifically for treating or reversing arteriosclerosis in humans remains limited. Most human studies focus on surrogate endpoints, such as improvements in blood pressure or endothelial function, rather than direct measurements of arterial plaque or stiffness. Systematic reviews and meta-analyses often highlight the need for larger, well-controlled trials to confirm these benefits. Therefore, while the mechanistic rationale and preliminary evidence are promising, the current level of evidence is moderate (rated 2 out of 5), and flavonols should be considered a supportive dietary component rather than a standalone treatment for arteriosclerosis.

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