Evidence supporting the use of: Flavanones (various)
For the health condition: Arteriosclerosis

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavanones, a subclass of flavonoids primarily found in citrus fruits, have been investigated for their potential cardiovascular benefits, including effects on arteriosclerosis (also known as atherosclerosis). Scientific studies—mainly preclinical and some clinical—suggest that flavanones such as hesperidin and naringenin possess antioxidant, anti-inflammatory, and lipid-lowering properties. These mechanisms are relevant because arteriosclerosis involves oxidative stress, inflammation, and lipid accumulation in arterial walls.

Animal studies have demonstrated that flavanones can reduce plaque formation and improve endothelial function. For example, hesperidin supplementation in rodents has been shown to decrease cholesterol levels and inhibit the progression of atherosclerotic lesions. Limited human clinical trials suggest that flavanone-rich diets (such as those including orange juice) may improve markers associated with arterial health, including blood pressure, endothelial function, and lipid profiles. However, these effects tend to be modest and not all trials show significant results.

Despite these promising findings, direct evidence from large, well-controlled human studies specifically targeting arteriosclerosis is lacking. Therefore, while the use of flavanones for arteriosclerosis is scientifically plausible and supported by mechanistic and early clinical evidence, the overall strength of evidence is still low to moderate (rated 2/5). More robust clinical trials are needed to conclusively establish efficacy in humans.

More about Flavanones (various)
More about Arteriosclerosis

Products containing Flavanones (various)

We currently have no products on Caring Sunshine that contain this ingredient.