Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Antioxidants have been investigated for their potential role in supporting or treating arteriosclerosis, primarily due to their ability to neutralize free radicals and reduce oxidative stress, which is believed to play a role in the pathogenesis of arterial hardening and atherosclerosis. Scientific studies have shown that oxidative modification of low-density lipoprotein (LDL) cholesterol is a key event in the development of atherosclerotic plaques. Antioxidants such as vitamin E, vitamin C, and beta-carotene have been considered as potential therapeutic agents for slowing or preventing this process.

However, the overall strength of the scientific evidence supporting the use of unspecified antioxidants for arteriosclerosis is limited. Large, randomized controlled trials, including the HOPE, HPS, and ATBC studies, have generally failed to demonstrate a significant benefit of antioxidant supplementation in reducing cardiovascular events or halting the progression of arteriosclerosis. Some observational studies have suggested a correlation between higher antioxidant intake and reduced risk, but these findings have not been consistently replicated in intervention trials. The American Heart Association and other major organizations do not recommend antioxidant supplements specifically for the prevention or treatment of arteriosclerosis, citing insufficient evidence of benefit.

In summary, while there is a scientific rationale and some preliminary evidence for the use of antioxidants in arteriosclerosis, high-quality clinical trials have not confirmed their efficacy, resulting in a modest evidence rating.

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