Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B complex, which includes several water-soluble vitamins such as B6 (pyridoxine), B9 (folate), and B12 (cobalamin), is scientifically validated for its role in supporting cardiovascular and arterial health. Numerous studies have shown that these vitamins help regulate homocysteine levels in the blood; elevated homocysteine is a well-established risk factor for atherosclerosis and other arterial diseases. A meta-analysis published in the New England Journal of Medicine (2002) and subsequent studies have demonstrated that supplementation with B6, B9, and B12 can significantly lower homocysteine levels, potentially reducing arterial stiffness and the risk of cardiovascular events.

However, while lowering homocysteine is consistently observed, the direct relationship between vitamin B supplementation and a reduction in major cardiovascular events (such as heart attack or stroke) is less clear. Large randomized controlled trials like the HOPE-2 study (2006) found significant homocysteine reduction but only modest or no significant impact on the incidence of cardiovascular events. Despite this, the mechanistic link between B vitamins, homocysteine metabolism, and arterial health is strong, and supplementation is often recommended in individuals with deficiencies or elevated homocysteine. Overall, vitamin B’s support for the arterial system is well-grounded in biochemical and clinical evidence, though its effect on major clinical outcomes is still an area of active research.

More about vitamin B
More about Arteries

Other ingredients that support Arteries

Other body systems supported by vitamin B

Products containing vitamin B