Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Inositol-stabilized arginine silicate (sometimes known by the branded name Nitrosigine) is primarily supported by scientific evidence for its role in supporting vascular function, particularly endothelial function and arterial blood flow. The compound is a combination of L-arginine (an amino acid precursor to nitric oxide), silicon (as silicate), and inositol. Several randomized, double-blind, placebo-controlled studies indicate that supplementation with inositol-stabilized arginine silicate can increase nitric oxide levels, leading to improved arterial dilation and blood flow. These effects have been shown in healthy adults and athletes, with some studies reporting improvements in flow-mediated dilation, a measure of endothelial function.

The mechanism relies on arginine being a precursor to nitric oxide, a key molecule in vasodilation. The addition of inositol and silicate is thought to enhance the bioavailability and stability of arginine, supporting sustained nitric oxide production. While the body of evidence is not extremely large and most studies are short-term and industry-sponsored, the available research does demonstrate positive effects on markers relevant to arterial health. There is not yet evidence for long-term cardiovascular outcomes, but the ingredient is used in supplements aimed at supporting circulation and arterial function based on these acute physiological effects.

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