Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Potassium chloride is scientifically validated for use in the management and prevention of certain cardiac arrhythmias, particularly those related to hypokalemia (low serum potassium). Potassium is a critical electrolyte that helps regulate the electrical activity of the heart. Hypokalemia can lead to increased myocardial excitability and prolongation of the QT interval, predisposing to dangerous arrhythmias such as ventricular tachycardia and fibrillation. Numerous clinical studies have demonstrated that correcting hypokalemia with potassium chloride reduces the risk of these arrhythmias, especially in hospitalized or critically ill patients and those on medications that deplete potassium (e.g., diuretics).

Current guidelines from major cardiology organizations, such as the American Heart Association (AHA) and European Society of Cardiology (ESC), recommend potassium supplementation to maintain serum potassium in the high-normal range (usually >4.0 mmol/L) in patients at risk for arrhythmia. Potassium chloride is the standard oral or intravenous preparation used for this purpose. The use of potassium chloride for arrhythmia is thus strongly evidence-based, with its efficacy and safety profile well-established in both acute and chronic settings. However, potassium should only be administered under medical supervision, as both deficiency and excess (hyperkalemia) can be life-threatening.

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