Evidence supporting the use of: Simmondsin
For the health condition: Appetite (excessive)
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Simmondsin is a bioactive compound found in jojoba seeds (Simmondsia chinensis). Its use to support or suppress excessive appetite is justified primarily by scientific research, particularly preclinical studies. Simmondsin has been shown in various animal studies to reduce food intake and body weight, suggesting an anorexigenic (appetite-suppressing) effect. The mechanism is believed to involve modulation of cholecystokinin (CCK) pathways, a hormone associated with satiety and appetite regulation. For instance, studies in rats have demonstrated that oral administration of simmondsin significantly decreases food intake, an effect that is attenuated by CCK receptor antagonists, supporting the involvement of CCK signaling.
However, while the preclinical evidence is fairly robust, there are currently no published clinical trials in humans confirming efficacy or safety for appetite suppression. The potential for toxicity at higher doses, as suggested by animal toxicity studies, further limits its applicability in humans. Additionally, regulatory agencies do not approve simmondsin as an appetite suppressant in any country. In summary, while there is scientific support from animal models for simmondsin's appetite-suppressing effects (evidence rating 3/5), the absence of human clinical data precludes a higher rating or broader therapeutic recommendation.
