Synopsis

Source of validity: Scientific
Rating (out of 5): 3

5-HTP (5-hydroxytryptophan) is a naturally occurring amino acid and chemical precursor in the biosynthesis of serotonin, a neurotransmitter involved in regulating mood and appetite. Scientific interest in 5-HTP for appetite suppression and weight management arises from its role in boosting central serotonin levels, which are known to contribute to feelings of satiety and reduced food intake. Several randomized controlled trials have explored its effects on appetite and weight in humans. For example, a 1992 double-blind study demonstrated that overweight women who took 5-HTP consumed significantly fewer calories and lost more weight compared to those on placebo (International Journal of Obesity, 1992). Other studies have reported similar findings, noting reduced carbohydrate intake and overall caloric consumption. The proposed mechanism is that increased serotonin levels in the brain enhance satiety signals, leading to decreased appetite. However, while results are promising, the overall number and quality of studies remain limited, and sample sizes tend to be small. Long-term safety data are also lacking, and potential side effects (such as nausea and gastrointestinal discomfort) may limit its use. Additionally, 5-HTP should not be combined with other serotonergic medications due to the risk of serotonin syndrome. In summary, there is moderate scientific evidence (rating: 3/5) that 5-HTP can help reduce appetite, but further research is needed to confirm its efficacy and safety for this purpose.

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