Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Undeca-2E, 7Z, 9E-trienoic acid isobutylamide is a principal alkamide found in Echinacea species, particularly Echinacea angustifolia and Echinacea purpurea. The traditional use of Echinacea has been primarily focused on immune support and reducing symptoms of colds and infections, rather than on stimulating appetite. However, some ethnobotanical reports indicate that Native American groups, such as the Plains tribes, used Echinacea root preparations for a variety of ailments, including as a tonic for general health and sometimes for supporting appetite in cases of debility or convalescence. There is, however, little direct historical documentation linking this specific compound or Echinacea extracts directly to appetite stimulation as a primary traditional use.

Scientifically, there are no robust clinical trials or mechanistic studies demonstrating that undeca-2E, 7Z, 9E-trienoic acid isobutylamide or Echinacea extracts enhance appetite in humans or animals. Most research has focused on immunomodulatory, anti-inflammatory, and analgesic effects. Therefore, while there is some weak ethnobotanical precedent for Echinacea being used as a general health tonic which may have, in some cases, supported appetite, there is limited direct traditional evidence and no scientific validation for this specific application.

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