Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Holarrhena, particularly Holarrhena antidysenterica, has a history of use in traditional medicine systems such as Ayurveda and Unani for a variety of gastrointestinal complaints, including loss of appetite (appetite deficiency). Classical Ayurvedic texts describe the use of Holarrhena bark (commonly known as Kutaja) for correcting digestive disturbances, improving appetite, and treating conditions like dysentery and diarrhea. The rationale is based on its reputed ability to stimulate digestive fire ("agni") and normalize bowel function, which in turn is believed to restore normal appetite. However, scientific studies directly investigating Holarrhena's effect on appetite stimulation are lacking. Most modern research has focused on its anti-diarrheal, anti-microbial, and anti-diabetic properties, with little direct clinical evaluation of its efficacy for treating deficient appetite. Therefore, the evidence for using Holarrhena to support appetite is rooted in long-standing traditional use rather than robust scientific validation. The evidence rating reflects the presence of traditional use but the absence of direct supporting clinical or preclinical studies.

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