Evidence supporting the use of: Phosphatidylserine complex
For the health condition: Anxiety Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Phosphatidylserine (PS) is a phospholipid found in high concentrations in the brain and has been investigated for its role in supporting cognitive function, stress response, and mood. Its use in anxiety disorders is supported by some preliminary scientific evidence, though this evidence is limited and not robust. Several small clinical studies have evaluated PS supplementation for its potential to modulate the hypothalamic-pituitary-adrenal (HPA) axis and reduce cortisol levels, especially in response to acute stress. For example, a 2004 study by Hellhammer et al. found that PS supplementation (in combination with phosphatidic acid) reduced the ACTH and cortisol response to stress and improved mood in healthy subjects. Another small trial suggested that PS might improve subjective feelings of stress and well-being.

However, direct evidence for PS specifically treating anxiety disorders is lacking. Most human studies have focused on cognitive decline, memory, or general stress rather than clinical anxiety diagnoses. Animal studies indicate possible anxiolytic effects, but translation to humans remains unclear. Systematic reviews generally conclude that while PS may help with stress adaptation, evidence for efficacy in anxiety disorders is insufficient and more research is needed. PS is not considered a first-line or evidence-based treatment for anxiety disorders by major psychiatric guidelines. In summary, there is limited scientific validation for using phosphatidylserine to support or treat anxiety disorders, with a low overall evidence rating.

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Products containing Phosphatidylserine complex

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