Evidence supporting the use of: Lactobacillus mixed)
For the health condition: Anxiety Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus (mixed strains) has garnered scientific interest for its potential role in supporting mental health, including anxiety disorders, via the gut-brain axis. Several preclinical and clinical studies suggest that certain probiotic strains, including those from the Lactobacillus genus, may have anxiolytic effects. Animal studies have shown that Lactobacillus supplementation can modulate neurotransmitter levels and reduce anxiety-like behaviors. Human studies, though limited and often small-scale, indicate some benefit. For instance, randomized controlled trials have reported that multispecies probiotics containing Lactobacillus can lead to modest reductions in anxiety scores among healthy adults and individuals with mild to moderate anxiety symptoms.

However, the evidence base is still developing. Systematic reviews and meta-analyses generally agree that, while promising, the current data is preliminary and heterogeneous, with variable strains, dosages, and outcome measures. No definitive clinical guidelines recommend Lactobacillus as a primary or adjunctive treatment for anxiety disorders at this time. The overall quality of evidence is moderate to low, and more robust, large-scale studies are needed to clarify efficacy and optimal strain selection.

In summary, while there is emerging scientific support for the use of mixed Lactobacillus strains in reducing anxiety symptoms, the evidence is not strong enough to warrant broad clinical endorsement. Interest in the microbiome’s impact on mental health continues to drive research in this area.

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