Evidence supporting the use of: Flavonoid
For the health condition: Anxiety Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavonoids are a diverse group of plant polyphenols found in many fruits, vegetables, and beverages like tea and wine. Their use for anxiety disorders is supported by a growing, albeit still preliminary, body of scientific research. Preclinical studies, mostly in animal models, have shown that certain flavonoids (such as apigenin, luteolin, quercetin, and chrysin) may exert anxiolytic (anxiety-reducing) effects. These effects are thought to be mediated by the modulation of neurotransmitter systems, particularly gamma-aminobutyric acid (GABA) receptors, which are also targeted by conventional anxiolytic drugs such as benzodiazepines. Some small-scale human studies and clinical trials have suggested modest benefits for anxiety symptoms with flavonoid-rich extracts (e.g., passionflower, chamomile), but the results are inconsistent and often limited by methodological weaknesses. Systematic reviews indicate that while there is potential, robust high-quality clinical evidence is still lacking, and most evidence comes from animal rather than human studies. There is also no specific flavonoid supplement or extract approved for the treatment of anxiety disorders. Thus, the use of flavonoids for anxiety is scientifically motivated but should be considered adjunctive and experimental at this stage. More well-designed clinical trials are necessary to confirm efficacy, optimal dosing, and safety in humans with anxiety disorders.

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