Evidence supporting the use of: Curcumin
For the health condition: Anxiety Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Curcumin, the main active compound in turmeric (Curcuma longa), has gained scientific interest for its potential role in supporting or treating anxiety disorders. While curcumin has a long history of use in traditional medicine for various ailments, its use specifically for anxiety is more recent and primarily based on emerging scientific research rather than traditional use for this particular condition.

Preclinical studies suggest that curcumin exerts anxiolytic (anxiety-reducing) effects, possibly by modulating neurotransmitter levels (such as serotonin and dopamine), reducing inflammation, and acting as an antioxidant. Animal studies have shown reduced anxiety-like behaviors following curcumin administration. A few small-scale, randomized controlled trials in humans have investigated curcumin supplementation in people with major depressive disorder, some of whom also had anxiety symptoms. These studies reported reductions in anxiety scores compared to placebo, but the sample sizes were small and the effect sizes modest.

The evidence is not yet robust, with most clinical studies limited by small cohorts, short duration, and variability in curcumin formulations and dosages. There is a need for larger, well-controlled clinical trials to establish efficacy and optimal dosing. Nonetheless, current findings provide preliminary support for curcumin as a potential adjunctive therapy for anxiety, justifying a moderate evidence rating. It should not replace standard treatments but may be considered as a complementary option under medical supervision.

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