Evidence supporting the use of: Vitamin B6
For the health condition: Anxiety

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine) has been investigated for its potential role in supporting or treating anxiety, with some scientific rationale behind its use, though the strength of evidence is limited. Vitamin B6 is essential in the synthesis of neurotransmitters such as serotonin, dopamine, and gamma-aminobutyric acid (GABA)—all of which play important roles in mood regulation and the anxiety response. Deficiency in B6 can lead to symptoms including irritability, confusion, and, in rare cases, anxiety-like symptoms. Several small-scale studies and clinical trials have explored the effect of B6 supplementation on anxiety. For instance, a 2022 randomized controlled trial found that high-dose vitamin B6 supplementation over one month led to a modest reduction in self-reported anxiety, possibly due to enhanced GABAergic activity. However, other studies have been mixed or inconclusive, and many have methodological limitations such as small sample size or lack of placebo controls. B6 is sometimes included in multivitamin formulations marketed for stress or mood support, and it is occasionally recommended by healthcare professionals for patients with confirmed B6 deficiency or as part of a broader strategy for supporting neurotransmitter balance. Nevertheless, there is not yet robust clinical evidence to support standalone vitamin B6 supplementation as an effective treatment for anxiety disorders in the general population. More large-scale, well-controlled studies are needed to clarify its therapeutic potential.

More about vitamin B6
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Other ingredients used for Anxiety

5-Hydroxytryptophan (5-HTP)
alpha-pinene
amino acids
ashwagandha
Waterhyssop
basil
benegut perilla (proprietary)
bergamot
beta caryophyllene
Bifidobacterium bifidum
Bifidobacterium infantis
Bifidobacterium lactis
Bifidobacterium longum
black cumin
bupleurum falcatum
California poppy
Cannabis sativa oil
chamomile
Chinese salvia root
citrus oil
clove
cordyceps
curcumin
damiana
DHA (docosahexaenoic acid)
epigallocatechin gallate (EGCG)
fennel
gardenia
ginkgo biloba
ginseng
gotu kola
Greek mountain tea
green tea
guayusa
hemp oil
hops
Indian tinospora
inositol
jujube
kava
kudzu
L-glycine
L-theanine
L-tryptophan
lactium casein decapeptide
Lactobacillus brevis
Lactobacillus fermentum
Lactobacillus gasseri
Lactobacillus helveticus
Lactobacillus paracasei
lactiplantibacillus plantarum
Lactobacillus reuteri
Lactobacillus rhamnosus
Lactobacillus salivarius
lavender
lion's mane
lithium orotate
maca
magnesium
magnolia
Matcha
Melatonin
Mint
Motherwort
Muira puama
N-acetyl-cysteine (NAC)
omega-3 fatty acids
passionflower
phellodendron amurense
phosphatidylserine
phytocannabinoids
polygala root
prebiotic blend (proprietary)
pregnenolone
pyridoxal-5-phosphate (P-5-P)
reishi mushroom
relora® (proprietary)
rhizome
Rhodiola
rose oil
rosemary
saffron
sage
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
sceletium
skullcap
spearmint leaf
Sphaeranthus indicus
thyme
Valerian root
velvet bean
vitamin B
vitamin B12
vitamin B6
vitamin C
Zinc
squawvine
catnip
gastrodia
cardamom
shen-chu
Mugwort
anise
Tinospora cordifolia
blackboard tree
peony
lingzhi
lemongrass
kanna
silk tree
chrysanthemum
ganoderma
sweet flag
oriental arborvitae
Menthol oil
St. John's Wort
Wood betony
herbal blend (proprietary)
indigo leaves
cocoa
soursop
geranium
star of Bethlehem
7,8-Dihydroxyflavone
ash
Agastache
alpha-terpineol
Ardisia
Agrimony
apigenin
anamu
Albizia
Aconite
Agmatine
Agarwood
Anemone
Alpha lactalbumin
Asteraceae
aniracetam
Amor seco
betony
black seed
Bifidobacterium
Baikal Skullcap
Bifidobacterium adolescentis
balsam
bayleaf
Bacopin
baicalein
brahmi
Bacopa
bee products
Bombax
bacteria
Bifidobacteria
Bupleurum
bacoside
baicalin
borneol
Camellia sinensis
Centella triterpenes
caryophyllene
Monkey flower
Cinnamomum
Clary sage
capillary artemisia
citron
Chinese raisintree
Cymbopogon martini
Calea zacatechichi
Centella asiatica
Capitate Valerian
Curcuma
catuaba
cowslip
cannabidiol
calamus
Clostridium butyricum
Convolvulus prostratus
Convolvulus pluricaulis
Clerodendrum indicum
Canscora
cannabigerol
dodeca-2E, 4E-dienoic acid isobutylamide
dragonhead
Erythrina
essential oil blend
eugenol
fragrant rosewood
Ficus religiosa
fatty acids
fungus
Gelsemium
Ginsenosides
Griffonia simplicifolia
Glycine
Gardenia jasminoides
gastrodin
Honokiol
Hyperoside
heal-all
Hypericum
hyperforin
Herb Robert
hericium mushroom
hemp
honeybush
iridoids
isoliquiritigenin
Ilex
Indian fagonia
jasmine
jujubosides
Jatamansi
kavalactones
Kefir
lemon balm
Lactobacillus plantarum
Lactucarium
Litsea
linden
Lactococcus rhamnosus
Lactucopicrin
ligustilides
limonene
longan
Lavandin
lotus
Lycopodium
Lactobacillus johnsonii
Large-leaved linden
lupulinum
linalool
Mentha haplocalyx
Myrcene
Marjoram
Mimulus
Monoterpenes
Mimosa
magnolol
Mulungu
Mesembrine
Nardostachys
Nigella seed
Nymphaea caerulea
Nymphaea nouchali
Nutmeg
Oroxylum indicum
oolong tea
Osmanthus
Oxindole alkaloids
Puerain
Phellodendron
Phenylpropanoids
Pulsatilla
prepared aconite tuber
Patchouli oil
probiotics
Passionfruit
paeoniflorin
poppy
Polygala
Petiveria
Plectranthus amboinicus
Purple Monkeyflower
rue
rosavins
Rauvolfia
rosmarinic acid
rose
Rooibos
Sophora
Speedwell
Scoparia dulcis
Sete sangrias
Sesquiterpenes
Sumbul
Self-Heal
Spikenard
Scleranthus annus
Salvia
Sensitive Plant
Southern Tsangshu
Southernwood
Salidroside
Shankhpushpi
Schisandrins
Sandalwood
Stachytarpheta cayennensis
Schizandrol A
Storax
Safranal
Sweet Orange alcohol
Terpenoids
Tea
Traveler's Joy
Trichilia catigua
Tagara
Tetrahydropalmatine
Uncaria
Vetiver
Valerenic acid
Vervain
Vitexin
Viburnum
Verbena
Violet
Vitex Agnus-Castus
Withanolides
White Tea
Wogonin
Xylaria nigripes
Yuzu
Yerba buena
Yohimbine
Ylang ylang

Products containing vitamin B6

Nature's Sunshine Love and Peas (Sugar Free Original Formula)
Nature's Sunshine 5-HTP Power
Nature's Sunshine Adrenal Support
Nature's Sunshine AIVIA Clean Energy
Nature's Sunshine AIVIA Plant Protein
Nature's Sunshine AIVIA Plant Protein
Nature's Sunshine AIVIA Whey Protein
Nature's Sunshine AIVIA Whey Protein
Nature's Sunshine Balanced B Complex (Vitamin B)
Nature's Sunshine Cardio Assurance
Nature's Sunshine Children's MultiVitamin & Mineral
Nature's Sunshine Glandular System
Nature's Sunshine Heavy Metal Detox
Nature's Sunshine Liquid - Methyl Vitamin B-12 Complete
Nature's Sunshine Love and Peas (Sugar Free) NEW!
Nature's Sunshine Love and Peas
Nature's Sunshine Mega-Chel
Nature's Sunshine MultiVitamin & Mineral (SynerPro)
Nature's Sunshine MultiVitamin & Mineral (Time Release)
Nature's Sunshine Natural Changes
Nature's Sunshine Nature's Prenatal
Nature's Sunshine Nature's Harvest
Nature's Sunshine Nervous System (30 Day Program)
Nature's Sunshine Nutri-Calm
Nature's Sunshine Nutri-Calm
Nature's Sunshine Power Beets Pouch
Nature's Sunshine Power Beets To-Go Packs
Nature's Sunshine Power Greens Pouch
Nature's Sunshine Power Greens To-Go
Nature's Sunshine Power Meal Chocolate
Nature's Sunshine Power Meal Vanilla
Nature's Sunshine Skeletal Strength
Nature's Sunshine Solstic Twenty-Four
Nature's Sunshine Solstic Energy
Nature's Sunshine Solstic Revive
Nature's Sunshine Structural System (30 Day Program)
Nature's Sunshine Super Supplemental
Nature's Sunshine Super Supplemental (Without Iron)
Nature's Sunshine Super Trio
Nature's Sunshine Thyroid Support
Nature's Sunshine B-Complex
Nature's Sunshine Vitamin B6
Nature's Sunshine VitaWave