Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B complex, particularly B6 (pyridoxine), B9 (folate), and B12 (cobalamin), has been investigated for its role in supporting mental health, including anxiety. Several studies have explored the relationship between B vitamin status and mood regulation, noting that deficiencies in these vitamins are associated with increased risk of mood disorders such as anxiety and depression. The biological rationale centers on the role of B vitamins in neurotransmitter synthesis (e.g., serotonin, dopamine, GABA), methylation, and homocysteine metabolism, all of which are relevant to brain function and mood stability.

Clinical trials provide modest support for the use of B vitamins in anxiety. Some randomized controlled trials (RCTs) have indicated that supplementation with B-complex vitamins may reduce perceived stress and improve mood, but the effects on clinically diagnosed anxiety disorders are less clear. For example, a 2011 RCT (Stough et al.) found that high-dose B-vitamin supplementation reduced workplace stress, while a 2019 meta-analysis (Young et al.) reported small but significant benefits for stress and mood, not specifically anxiety. Evidence for direct effects on anxiety, particularly in populations without deficiency, remains limited and inconsistent.

In summary, while there is a scientific rationale for ensuring adequate B vitamin status to support overall brain health, current evidence for their use specifically to treat or prevent anxiety is limited and rated as low to moderate. Supplementation may be most beneficial in individuals with known deficiencies.

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