Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Saffranal is a major volatile constituent of saffron (Crocus sativus L.) and is partly responsible for saffron’s distinct aroma. Its use for anxiety is supported by some preliminary scientific evidence, though the data is limited and primarily preclinical. Several animal studies have demonstrated that saffranal possesses anxiolytic-like effects, possibly through modulation of the GABAergic system, which is a common mechanism among conventional anxiolytic drugs. For example, a study published in "Phytotherapy Research" (2007) found that saffranal reduced anxiety-like behaviors in mice in both the elevated plus maze and open field tests, and these effects were comparable to diazepam at certain doses. Furthermore, another rodent study in "Planta Medica" (2004) noted similar anxiolytic-like activity from saffron extracts containing saffranal.

Human evidence, however, is scarce. Most clinical studies on saffron and anxiety have focused on whole saffron extracts rather than isolated saffranal, making it challenging to attribute effects specifically to saffranal. The overall clinical data on saffron suggests mild to moderate benefits for mood and anxiety symptoms, but saffranal’s independent role remains unclear. Thus, while there is some scientific basis, especially from animal studies, more rigorous human trials are necessary to confirm saffranal’s efficacy and safety for anxiety treatment.

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