Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Polyphenols are a diverse group of naturally occurring compounds found in plants, known for their antioxidant and anti-inflammatory properties. In recent years, there has been growing scientific interest in their potential role in supporting mental health, including anxiety. Several preclinical (animal) studies and a limited number of human clinical trials suggest that certain polyphenols—such as flavonoids (e.g., quercetin, epigallocatechin gallate from green tea, and resveratrol)—may exert anxiolytic (anxiety-reducing) effects. The proposed mechanisms include modulation of neurotransmitter systems (e.g., GABA, serotonin, dopamine), reduction of oxidative stress, and anti-inflammatory effects in the brain. However, the overall quality and quantity of clinical evidence remain limited. Most human studies are small, short-term, and sometimes use polyphenol-rich extracts rather than isolated compounds, making it difficult to determine which specific polyphenols are effective or the optimal dosage. A 2022 systematic review noted potential benefits of polyphenol supplementation for anxiety but concluded that evidence is preliminary and further high-quality randomized controlled trials are needed. Thus, while there is a scientific rationale and preliminary evidence supporting polyphenols’ use for anxiety, it is not yet robust or conclusive.

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