Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Phosphatidylserine (PS) is a phospholipid found in high concentrations in the brain and is involved in cell signaling and the maintenance of neuronal membrane integrity. Its use for anxiety is primarily based on scientific investigation, though the evidence is limited and not robust. Several small studies have explored the effects of phosphatidylserine supplementation on stress and cortisol levels, which can be indirectly related to anxiety. For example, a few randomized controlled trials have reported that phosphatidylserine supplementation (typically 200-400 mg/day) may help attenuate the rise in cortisol and perceived stress during challenging situations, such as mental or physical stress tests. Some of these studies have found modest reductions in stress-induced symptoms and improvements in mood, which could be interpreted as having a potential anti-anxiety effect. However, direct high-quality evidence supporting phosphatidylserine specifically for the treatment of clinical anxiety disorders is limited. Most research focuses on stress rather than anxiety per se, and sample sizes have generally been small. There are also studies that show no significant benefit. Meta-analyses and systematic reviews do not provide strong support for its use in anxiety treatment, and major clinical guidelines do not recommend it as a frontline therapy. In summary, while there is some scientific rationale and preliminary evidence for phosphatidylserine’s use in supporting stress resilience—which may overlap with anxiety—overall the scientific backing is weak, and more rigorous, larger-scale studies are needed.

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