Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Omega-3 fatty acids, particularly EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), have been studied as a potential adjunctive therapy for anxiety disorders. The scientific rationale is based on their anti-inflammatory properties and their role in modulating neurotransmitter function, neurogenesis, and neuronal membrane fluidity. Several randomized controlled trials (RCTs) and meta-analyses have investigated the effects of omega-3 supplementation on anxiety symptoms, both in clinical populations and in healthy individuals. A 2018 meta-analysis published in JAMA Network Open reviewed 19 clinical trials and found that omega-3 supplementation was associated with a modest reduction in anxiety symptoms compared to placebo, particularly in individuals with clinical anxiety. However, the overall effect size was small, and study quality varied. Another 2023 systematic review concluded that while there is some evidence for anxiolytic effects, results are inconsistent and more large-scale, high-quality trials are needed. Importantly, the anxiolytic effects appear more robust when the EPA content is higher relative to DHA. In summary, while there is some scientific evidence suggesting omega-3 fatty acids may help reduce anxiety, the magnitude of benefit is modest and not universally observed. Omega-3 is not a first-line treatment for anxiety, but it may be considered as an adjunct, especially in individuals with low omega-3 intake or coexisting depression. The evidence base warrants a modest rating, reflecting promising but inconclusive data.

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Products containing omega-3 fatty acids

Nature's Sunshine Flax Seed Oil (With Lignans)