Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactiplantibacillus plantarum is a probiotic bacterium commonly found in fermented foods and available as a dietary supplement. There is an emerging body of scientific evidence suggesting a link between gut microbiota and mental health, particularly anxiety and depression—a relationship often referred to as the "gut-brain axis." Several preclinical (animal) studies have shown that L. plantarum strains can reduce anxiety-like behavior, likely by modulating inflammation, neurotransmitter levels, and gut barrier function. For example, rodent studies have reported reduced anxiety markers and improved stress resilience following supplementation with L. plantarum. Human research, however, is still limited and generally of low to moderate quality. A few small randomized controlled trials (RCTs) have reported that supplementation with L. plantarum (often in combination with other probiotics) can reduce subjective anxiety scores or improve stress responses in healthy adults or individuals under stress. One study (2021) found that L. plantarum PS128 reduced anxiety and improved mood in athletes. However, sample sizes are typically small, strains and dosages vary, and some studies show no significant benefits. Overall, while the concept is scientifically plausible and supported by preliminary evidence, robust clinical data is lacking. The evidence is promising but not yet strong enough for definitive therapeutic recommendations. Thus, L. plantarum for anxiety is scientifically grounded, but the level of evidence is currently low to moderate.

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