Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Jujube seeds (Ziziphus jujuba), also known as "suan zao ren" in traditional Chinese medicine (TCM), have been used for centuries in East Asian herbal practices to promote calmness and treat symptoms such as insomnia, irritability, and anxiety. Historical texts and materia medica from Chinese medicine describe jujube seeds as nourishing the heart and calming the spirit ("shen"), making them a common component in formulas intended to alleviate anxiety and related sleep disturbances.

Scientific research on jujube seeds for anxiety is limited and mostly preclinical. Some animal studies suggest extracts of jujube seeds may exhibit anxiolytic (anxiety-reducing) effects, potentially due to compounds such as saponins, flavonoids, and jujubosides, which may interact with neurotransmitter systems (such as GABAergic pathways) involved in anxiety regulation. However, robust, well-designed human clinical trials are lacking, and thus the evidence for efficacy in treating anxiety in humans remains weak.

In summary, while there is a strong tradition of using jujube seeds for anxiety in TCM, scientific validation is currently limited to preliminary studies, and more rigorous human research is needed to confirm efficacy and safety.

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