Synopsis

Source of validity: Scientific
Rating (out of 5): 2

DHA (docosahexaenoic acid) is an omega-3 fatty acid predominantly found in fish oil and is a key structural component of the brain. The scientific rationale for using DHA to support or treat anxiety is based on its role in maintaining neuronal membrane fluidity, modulating neurotransmitter function, and reducing neuroinflammation. Several observational studies have found correlations between low dietary intake of omega-3 fatty acids (including DHA) and increased prevalence of mood and anxiety disorders. However, clinical trials specifically examining DHA supplementation for anxiety have yielded mixed results.

A 2018 meta-analysis (Grosso et al., 2018) found that omega-3 supplementation may have a small but significant effect in reducing anxiety symptoms, but most studies used EPA-dominant formulations or mixed EPA/DHA, making it unclear how much benefit is attributable to DHA alone. Some individual RCTs have tested DHA-rich formulations and reported modest reductions in anxiety symptoms, but these results are not consistent across all populations and the effect size is generally small.

In summary, while there is some scientific evidence suggesting that DHA (often in combination with EPA) may help reduce anxiety symptoms, the overall quality and consistency of the evidence is moderate at best. DHA is not universally recognized as a primary treatment for anxiety, but its use is supported to a limited degree by current scientific research.

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