Evidence supporting the use of: Curcumin
For the health condition: Anxiety

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Curcumin, the main active compound in turmeric (Curcuma longa), has garnered interest for its potential anxiolytic (anxiety-reducing) effects. Scientific studies suggest that curcumin may influence neurotransmitter balance, neuroinflammation, and oxidative stress, all of which are implicated in the pathophysiology of anxiety disorders. Preclinical studies in animal models have shown that curcumin supplementation can reduce anxiety-like behaviors, possibly by modulating serotonin and dopamine pathways and reducing inflammation in the brain.

Some small-scale human clinical trials have also explored curcumin's effects on mood. A few randomized controlled trials have reported modest improvements in anxiety symptoms among individuals taking curcumin supplements, particularly in populations with comorbid depression or chronic health conditions. However, these studies are generally limited by small sample sizes, short durations, and methodological shortcomings. Meta-analyses and systematic reviews acknowledge a possible benefit but emphasize the need for larger, high-quality trials before curcumin can be widely recommended for anxiety.

In summary, while there is emerging scientific evidence suggesting curcumin may have anxiolytic properties, the current body of evidence is preliminary and not robust. The evidence rating is therefore 2 out of 5, indicating weak but suggestive scientific support, rather than strong or conclusive evidence. More rigorous clinical research is needed to firmly establish curcumin’s efficacy and optimal dosing for the treatment of anxiety.

More about curcumin
More about Anxiety

Other ingredients used for Anxiety

5-Hydroxytryptophan (5-HTP)
alpha-pinene
amino acids
ashwagandha
waterhyssop
basil
benegut perilla (proprietary)
bergamot
beta caryophyllene
bifidobacterium bifidum
bifidobacterium infantis
bifidobacterium lactis
bifidobacterium longum
black cumin
bupleurum falcatum
California poppy
cannabis sativa oil
chamomile
Chinese salvia root
citrus oil
clove
cordyceps
curcumin
damiana
DHA (docosahexaeonic acid)
epigallocatechin gallate (EGCG)
fennel
gardenia
ginkgo biloba
ginseng
gotu kola
greek mountain tea
green tea
guayusa
hemp oil
hops
Indian tinospora
inositol
jujube
kava root
kudzu
l-glycine
l-theanine
l-tryptophan
lactium casein decapeptide
lactobacillus brevis
lactobacillus fermentum
lactobacillus gasseri
lactobacillus helveticus
lactobacillus paracasei
lactiplantibacillus plantarum
lactobacillus reuteri
lactobacillus rhamnosus
lactobacillus salivarius
lavender
lion's mane
lithium orotate
maca
magnesium
magnolia
matcha
melatonin
mint
motherwort
muira puama
n-acetyl-cysteine (NAC)
omega-3 fatty acids
passionflower
phellodendron amurense
phosphatidylserine
phytocannabinoids
polygala root
prebiotic blend (proprietary)
pregnenolone
pyridoxal-5-phosphate (P-5-P)
reishi mushroom
relora® (proprietary)
rhizome
rhodiola
rose oil
rosemary
saffron
sage
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sceletium
skullcap
spearmint leaf
sphaeranthus indicus
thyme
valerian root
velvet bean
vitamin B
vitamin B12
vitamin B6
vitamin C
zinc
squawvine
catnip
gastrodia
cardamom
shen-chu
mugwort
anise
tinospora cordifolia
blackboard tree
peony
lingzhi
lemongrass
kanna
silk tree
chrysanthemum
ganoderma
sweet flag
oriental arborvitae
menthol oil
St. John's Wort
wood betony
hypothalamus
herbal blend (proprietary)
indigo leaves
cocoa
soursop
geranium
7,8-Dihydroxyflavone
Ash
Agastache
Alpha-terpineol
Ardisia
Agrimony
Apigenin
Anamu
Albizia
Aconite
Agmatine
Agarwood
Anemone
Alpha lactalbumin
Asteracea
Aniracetam
Amor seco
Betony
Black Seed
Bifidobacterium
Baikal Skullcap
Bifidobacterium adolescentis
Balsam
Bayleaf
Bacopin
Baicalein
Brahmi
Bacopa
Bee products
Bombax
Bacteria
Bifidobacteria
Bupleurum
bacoside
Baicalin
Borneol
Camellia sinensis
Centella triterpenes
Caryophyllene
Common Monkey Flower
Cinnamomum
Clary sage
Capillary Artemisia
Citron
Chinese Raisintree
Cymbopogon Martini
Calea zacatechichi
Centella asiatica
Capitate Valerian
Curcuma
Catuaba
Cowslip
Cannabidiol
Calamus
Clostridium butyricum
Convolvulus prostratus
Convolvulus Pluricaulis
Clerodendrum indicum
Canscora
Cannabigerol
Dodeca-2E, 4E-Dienoic Acid Isobutylamide
Dragonhead
Glycine
jasmine
Lotus
Mimosa
Poppy
Rose
Spikenard
Sandalwood
Sweet Orange alcohol
Vervain
yohimbine