Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bifidobacteria, a genus of probiotic bacteria commonly found in the human gut, has been investigated for its potential role in supporting or treating anxiety. The scientific evidence for its use is still emerging and can be considered preliminary. Several small-scale human studies and animal models suggest that certain strains of Bifidobacteria may have anxiolytic (anxiety-reducing) effects, likely through modulation of the gut-brain axis. For example, a 2011 study published in PNAS found that Bifidobacterium longum NCC3001 normalized anxiety-like behavior in mice with induced colitis, possibly by altering vagal nerve signaling. Some human clinical trials, such as those using Bifidobacterium longum 1714, reported reduced stress and improved memory in healthy volunteers. A 2017 randomized controlled trial in Translational Psychiatry showed that B. longum 1714 supplementation resulted in modest reductions in stress and mild anxiety symptoms. However, these trials generally involve small sample sizes, short durations, and sometimes lack replication.

Overall, while there is scientific interest and some preliminary evidence for the use of Bifidobacteria in anxiety, the body of evidence is not yet robust. Larger and more rigorous clinical trials are needed to confirm efficacy and determine which strains and dosages are most effective. Currently, Bifidobacteria cannot be considered a primary or established treatment for anxiety, but research is ongoing.

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