Synopsis

Source of validity: Scientific
Rating (out of 5): 2

5-HTP (5-hydroxytryptophan) is a naturally occurring amino acid and chemical precursor in the biosynthesis of serotonin, a neurotransmitter implicated in mood regulation and anxiety. The rationale for using 5-HTP to support or treat anxiety is based on its ability to increase serotonin levels in the brain, which may help improve mood and reduce anxiety symptoms. Several small-scale clinical studies and animal research have explored this connection. Some studies suggest that 5-HTP supplementation can reduce symptoms of anxiety, particularly in individuals with comorbid depression or those suffering from conditions like panic disorder. However, the evidence is mixed and often limited by small sample sizes, short durations, or methodological flaws.

A 2012 review published in “Neuropsychiatric Disease and Treatment” notes that while there is a plausible biological mechanism, robust randomized controlled trials examining 5-HTP specifically for anxiety are lacking. Most studies have focused on depression rather than anxiety, and those that address anxiety often include it as a secondary outcome. Additionally, concerns exist regarding side effects and safety, especially when used with other serotonergic agents, due to the risk of serotonin syndrome.

In summary, there is some preliminary scientific evidence that supports the use of 5-HTP for anxiety, but it is not strong or conclusive. More rigorous, large-scale clinical trials are needed to clearly establish its efficacy and safety for this indication.

More about 5-Hydroxytryptophan (5-HTP)
More about Anxiety

Other ingredients used for Anxiety

Other health conditions supported by 5-Hydroxytryptophan (5-HTP)

Products containing 5-Hydroxytryptophan (5-HTP)

Nature's Sunshine 5-HTP Power