Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Saccharomyces cerevisiae, particularly the strain Saccharomyces boulardii, is well-supported by scientific evidence for use in preventing and treating antibiotic-associated side effects, especially diarrhea. Multiple randomized controlled trials and meta-analyses have shown that supplementation with S. boulardii can significantly reduce the incidence and severity of antibiotic-associated diarrhea (AAD) in both adults and children. The mechanism of action appears to involve restoration of gut microbiota balance disrupted by antibiotics, inhibition of pathogenic bacteria, and modulation of the immune response. Furthermore, S. boulardii produces enzymes and proteins that can neutralize bacterial toxins and improve intestinal barrier function.

Clinical guidelines from organizations such as the European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) recommend the use of S. boulardii as a probiotic for the prevention of AAD. It is important to note that the evidence specifically pertains to S. boulardii, a subtype of S. cerevisiae, rather than all strains of S. cerevisiae. The use of S. boulardii is generally considered safe for the general population, though caution is advised in immunocompromised patients due to rare cases of fungemia. Overall, the use of S. cerevisiae (specifically S. boulardii) for mitigating antibiotic side effects is well validated by scientific research.

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