Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Pediococcus acidilactici is a species of lactic acid bacteria that has been explored as a probiotic, particularly for its potential to support gastrointestinal health during or after antibiotic therapy. Antibiotics can disrupt the natural gut microbiota, leading to side effects such as diarrhea, including antibiotic-associated diarrhea (AAD) and Clostridioides difficile infection. The rationale for using P. acidilactici is based on its ability to survive the acidic environment of the stomach, adhere to intestinal mucosa, and produce antimicrobial substances that can inhibit pathogenic bacteria.

Several studies have examined the use of P. acidilactici, often in combination with other probiotic strains, for the prevention or mitigation of antibiotic-associated side effects. Some clinical trials and in vitro studies have shown that formulations containing P. acidilactici (such as Pediococcus acidilactici CNCM I-4622) can help maintain gut microbial balance and reduce the incidence and severity of diarrhea in people taking antibiotics. However, the quality and quantity of clinical evidence specific to P. acidilactici (as opposed to broader multi-strain probiotics) is still limited, and it is not as extensively studied as other probiotics like Lactobacillus or Saccharomyces boulardii.

In summary, there is moderate scientific evidence supporting P. acidilactici as a probiotic to reduce some side effects of antibiotics, primarily based on its role in gut microbiota modulation. However, more rigorous, large-scale clinical trials are needed to establish its efficacy and optimal usage.

More about Pedicoccus acidilactici
More about Antibiotics (side effects of)

Other ingredients used for Antibiotics (side effects of)

Other health conditions supported by Pedicoccus acidilactici

Products containing Pedicoccus acidilactici