Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Lactobacillus (mixed strains) is commonly used as a probiotic to help support gastrointestinal health, especially in the context of antibiotic use. Antibiotics, while effective against bacterial infections, often disrupt the natural balance of gut microbiota, leading to side effects such as diarrhea, including antibiotic-associated diarrhea (AAD) and, in severe cases, Clostridioides difficile infection. Several randomized controlled trials and meta-analyses have shown that supplementation with probiotics containing Lactobacillus strains can reduce the risk and severity of AAD, particularly in children and adults.

A 2012 Cochrane review encompassing 23 randomized controlled trials found that probiotics (primarily Lactobacillus species) reduced the risk of AAD by approximately 42%, with similar findings in more recent systematic reviews. The mechanism is thought to involve competition with pathogenic bacteria, restoration of the gut microbial balance, and modulation of immune responses.

These positive effects appear to be strain-specific and dose-dependent, with the strongest support for certain species such as Lactobacillus rhamnosus GG and Lactobacillus casei. The safety profile is generally favorable in healthy populations, though caution is warranted in immunocompromised individuals.

Overall, the use of mixed Lactobacillus probiotics to support gut health and reduce antibiotic side effects is supported by moderate to strong scientific evidence, particularly for preventing antibiotic-associated diarrhea.

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