Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Lactobacillus delbrueckii, although not as extensively studied as some other probiotic strains like Lactobacillus rhamnosus GG or Saccharomyces boulardii, is a lactic acid bacterium commonly found in fermented dairy products such as yogurt. The use of Lactobacillus delbrueckii to mitigate the gastrointestinal side effects of antibiotics—most notably antibiotic-associated diarrhea (AAD)—is grounded in the broader scientific evidence supporting the efficacy of certain lactobacilli and probiotics. Antibiotic use often disrupts the balance of the gut microbiota, potentially leading to overgrowth of pathogenic bacteria such as Clostridioides difficile, and resulting in symptoms like diarrhea.

Studies have shown that probiotic supplementation can reduce the incidence and severity of AAD in both children and adults. While most clinical trials and meta-analyses focus on other strains, Lactobacillus delbrueckii is a component of traditional yogurt cultures (often paired with Streptococcus thermophilus), and consumption of such yogurts has been shown in several studies to help restore gut microbial balance during and after antibiotic therapy. The mechanism involves competitive exclusion of pathogens and modulation of the immune response.

However, because direct, high-quality clinical trials specifically with L. delbrueckii are relatively limited compared to other strains, the evidence for its efficacy is moderate. The rating of 3 reflects supportive, but not definitive, scientific validation for its use in mitigating the side effects of antibiotics.

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