Evidence supporting the use of: Colostrum
For the health condition: Antibiotics (side effects of)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Colostrum, the first form of milk produced by mammals immediately following delivery, is rich in immunoglobulins, growth factors, and antimicrobial peptides. Its use to support gut health during or after antibiotic therapy is backed by a moderate level of scientific evidence, particularly in the context of preventing or mitigating antibiotic-associated diarrhea (AAD). Several randomized controlled trials and meta-analyses have examined bovine colostrum’s potential to maintain intestinal barrier integrity, promote beneficial gut flora, and reduce gastrointestinal disturbances after antibiotic use.

Colostrum contains bioactive compounds such as lactoferrin, immunoglobulins (IgG, IgA), and growth factors that may help restore the gut mucosa and support immune function compromised by antibiotics. Studies have found that colostrum supplementation can decrease the incidence and severity of diarrhea in both children and adults receiving antibiotics, and may help prevent Clostridioides difficile infection, a serious complication of antibiotic therapy. However, while the evidence is promising, it is not as robust or conclusive as that for probiotics, which are more commonly recommended for this purpose. The mechanisms underlying colostrum’s benefit include its ability to inhibit pathogenic bacteria, reduce inflammation, and support the regeneration of enterocytes.

In summary, there is moderate scientific validation for the use of colostrum to support gut health and counteract certain side effects of antibiotics, especially diarrhea. More large-scale, high-quality studies are needed to define optimal dosing and long-term efficacy.

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