Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Bacillus subtilis natto is a probiotic bacterium commonly found in the traditional Japanese food natto. Its use to support or treat side effects of antibiotics—primarily antibiotic-associated diarrhea (AAD) and gut dysbiosis—has scientific backing, although not as extensive as that for other probiotics like Lactobacillus or Saccharomyces boulardii. Several studies have explored the efficacy of B. subtilis (including natto strains) in restoring gut microbiota balance and reducing gastrointestinal side effects following antibiotic use. For instance, randomized controlled trials in humans have demonstrated that supplementation with B. subtilis natto can reduce the incidence and severity of diarrhea during antibiotic therapy, likely due to its ability to survive gastric acidity, colonize the gut, and produce antimicrobial compounds that inhibit pathogenic bacteria. Additionally, B. subtilis produces enzymes and vitamins that may aid in gut recovery post-antibiotics. Meta-analyses and reviews acknowledge B. subtilis as a promising probiotic for AAD prevention, though they also note that the body of evidence is smaller and sometimes less consistent compared to other established probiotics. In summary, while more large-scale, high-quality clinical trials are needed, there is moderate scientific evidence supporting the use of Bacillus subtilis natto to help mitigate some side effects of antibiotics, especially digestive disturbances.

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