Evidence supporting the use of: Branched-Chain Amino Acids
For the health condition: Anorexia

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Branched-Chain Amino Acids (BCAAs)—including leucine, isoleucine, and valine—have been investigated for their potential benefits in supporting individuals with anorexia, particularly anorexia nervosa. The rationale for their use is based on the essential role of BCAAs in muscle protein synthesis and their ability to help prevent muscle wasting, a common complication in anorexic patients due to prolonged malnutrition and catabolism. Scientific studies have explored whether BCAA supplementation can help preserve lean body mass and improve nutritional status during refeeding and recovery.

While some small clinical trials and case reports suggest that BCAA supplementation might help attenuate muscle breakdown and support protein synthesis in severely malnourished individuals, the overall quality and quantity of evidence remain limited. Most research consists of pilot studies or animal models, and large, randomized controlled trials in anorexia nervosa patients are scarce. Some studies report improved nitrogen balance and muscle mass maintenance, but results are inconsistent and often confounded by other nutritional interventions.

Current clinical guidelines do not universally recommend BCAAs as a standard treatment for anorexia nervosa, but their use may be considered in certain cases of severe malnutrition or sarcopenia. In summary, there is some scientific basis for the use of BCAAs in anorexia, but the evidence supporting their effectiveness is modest and not definitive.

More about Branched-Chain Amino Acids
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