Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Inositol nicotinate, also known as hexanicotinate, has traditionally been used in some European countries as a vasodilator for the treatment of peripheral vascular diseases and, to a lesser extent, angina pectoris (chest pain due to reduced blood flow to the heart). The rationale behind its use is that it can release nicotinic acid (niacin) slowly in the body, leading to vasodilation (widening of blood vessels) and improved blood flow. This may theoretically reduce the frequency and severity of angina attacks. However, scientific evidence supporting the use of inositol nicotinate specifically for angina is limited and dated. Most available studies were small, conducted several decades ago, and often lacked rigorous design by today's standards. Some early trials reported modest improvements in symptoms or exercise tolerance, but these findings have not been consistently reproduced or confirmed by larger, high-quality studies. Modern guidelines for the management of angina do not include inositol nicotinate, and it is not widely used for this indication outside of a few regions where tradition persists. In summary, while inositol nicotinate has a tradition of use for angina, robust scientific validation is lacking. Its use is largely historical, and it has not been established as an effective or recommended therapy for angina in contemporary clinical practice.

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